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Thomas Flatt

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Fabian, D, Kapun, M., Nolte, V., Kofler, R., Schmidt, P.S., Schlötterer, C., Flatt, T. 2012. Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America. Molecular Ecology, published online: 22 August 2012. DOI: 10.1111/j.1365-294X.2012.05731.x Pdf

Flatt, T. 2012. A new definition of aging? Frontiers in Genetics 3:148. doi:10.3389/fgene.2012.00148. Pdf

Rose, M.R., Flatt, T., Graves, J.L., Greer, L., Martinez, D.E., Matos, M.M., Mueller, L.D., Shmookler Reis, R.J., and P. Shahrestani. 2012. What is aging? Frontiers in Genetics 3:134.doi: 10.3389/ fgene.2012.00134. Pdf

Orozco-terWengel, P., Kapun, M., Nolte, V., Kofler, R., Flatt, T., Schlötterer, C. 2012. Adaptation of Drosophila to a novel laboratory environment reveals temporally heterogeneous trajectories of selected alleles. Molecular Ecology, published online: 21 June 2012. DOI: 10.1111/j.1365-294X.2012.05673.x (Cover Article). Pdf

Fabian, D., Flatt, T. 2012. Life history evolution. Nature Education Knowledge3(8):24. Pdf

Fabian, D., Flatt, T. 2011. The evolution of aging. Nature Education Knowledge 2(11):9. Pdf

Flatt, T., Heyland, A., Stearns, S.C. 2011. What mechanistic insights can or cannot contribute to life history evolution - an exchange between Stearns, Heyland, and Flatt. Chapter 28 (Pp. 375-379) in: Flatt, T. and Heyland, A. (Editors), Mechanisms of Life History Evolution. The Genetics and Physiology of Life History Traits and Trade-Offs. Oxford University Press, Oxford, UK. Pdf

Braendle, C., Heyland, A., Flatt, T. 2011. Integrating mechanistic and evolutionary analysis of life history variation. Chapter 1 (Pp. 3-10) in: Flatt, T. and Heyland, A. (Editors), Mechanisms of Life History Evolution. The Genetics and Physiology of Life History Traits and Trade-Offs. Oxford University Press, Oxford, UK. Pdf

Flatt, T., Heyland, A. (Editors). 2011. Mechanisms of Life History Evolution. The Genetics and Physiology of Life History Traits and Trade-Offs. Oxford University Press, Oxford, UK. 478 Pages. More Information on the Book

Klepsatel, P., Flatt, T. 2011. The genomic and physiological basis of life history variation in a butterfly metapopulation. Molecular Ecology 20:1795-1798. Pdf

Flatt, T. 2011. Survival costs of reproduction in Drosophila. Experimental Gerontology 46:369-375. Pdf

Galikova, M., Klepsatel, P., Senti, G., Flatt, T. 2011. Steroid hormone regulation of C. elegans and Drosophila aging and life history. Experimental Gerontology 46:141-147. Pdf

Bronikowski, A.M., Flatt, T. 2010. Aging and its demographic measurement. Nature Education Knowledge 1(12):3. Pdf

Kapun, M., Nolte, V., Flatt, T., Schlötterer, C. 2010. Natural host range and host specificity of the Drosophila C virus. PLoS One 5(8):e12421. Pdf

Galikova, M., Flatt, T. 2010. Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout. Aging 2:387-390. Pdf

Vogl, C., Flatt, T., Fuhrmann, B., Hofmann, E., Wallner, B., Kovarik, P., Srobl, B., and M. Müller. 2010. Transcriptome analysis reveals a major impact of tyrosine kinase 2 (Tyk2) on the expression of interferon responsive and metabolic genes. BMC Genomics 2010 Mar 25;11(1):199. Pdf

Flatt, T. 2009. Ageing: diet and longevity in the balance. Nature 462:989-990. Pdf

Flatt, T., and P.S. Schmidt. 2009. Integrating evolutionary and molecular genetics of aging. Biochimica et Biophysica Acta 1790:951-962. Pdf

Bauer, J.H., Morris, S.N.S., Chang, C., Flatt, T., Wood, J.G., and S.L. Helfand. 2009. dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster. Aging 1(1):38-48. Pdf

Flatt, T., Heyland, A., Rus, F., Porpiglia, E., Sherlock, C., Yamamoto, R., Garbuzov, A., Palli, S.R., Tatar, M., and N. Silverman. 2008. Hormonal regulation of the humoral innate immune response in Drosophila melanogaster. Journal of Experimental Biology 211: 2712-2724. Pdf

Flatt, T., Min, K.-J., D’Alterio, C., Villa-Cuesta, E., Cumbers, J., Lehmann, R., Jones, D.L., and M. Tatar. 2008. Drosophila germ-line modulation of insulin signaling and lifespan. Proceedings of the National Academy of Sciences USA 105:6368-6373. Pdf

Crook, T.C., Flatt, T., and P.T. Smiseth. 2008. Hormonal modulation of larval begging and growth in the burying beetle Nicrophorus vespilloides. Animal Behaviour 75:71-77. Pdf

Flatt, T., and D.E.L. Promislow. 2007. Physiology: still pondering an age-old question. Science 318:1255-1256. Pdf

Flatt, T., and T.J. Kawecki. 2007. Juvenile hormone as a regulator of the trade-off between reproduction and life span in Drosophila melanogaster. Evolution 61:1980-1991. Pdf

Shingleton, A., Frankino, W.A., Flatt, T., Nijhout, H.F., and D. Emlen. 2007. Size and shape: the developmental regulation of static allometry in insects. BioEssays 29:536-548. Pdf

Min, K.-J., Flatt, T., Kulaots, I., and M. Tatar. 2007. Counting calories in Drosophila dietary restriction. Experimental Gerontology 42:247-251. Pdf

Flatt, T., Moroz, L. L., Tatar, M., and A. Heyland. 2006. Comparing thyroid and insect hormone signaling. Integrative & Comparative Biology 46:777-794. Pdf

Bishop, C., Erezyilmaz, D.F., Flatt, T., Georgiou, C.D., Hadfield, M., Heyland, A., Hodin, J., Jacobs, M., Maslakova, S.A., Pires, A., Reitzel, A., Santagata, S., Tanaka, K., and J.H. Youson, 2006. What is metamorphosis? Integrative & Comparative Biology 46:655-661. Pdf

Braendle, C., and T. Flatt. 2006. A role for genetic accommodation in evolution? BioEssays 28:868-873. Pdf

Killingback, T., Bieri, J., and T. Flatt. 2006. Evolution in group-structured populations can resolve the tragedy of the commons. Proceedings of the Royal Society of London B 273:1477-1481. Pdf

Flatt, T. 2006. Life history pleiotropy mediated by Methoprene-tolerant, a putative juvenile hormone receptor. Journal of Experimental Zoology A – Comparative Experimental Biology 305A:126. (Published Abstract)

Tu, M.P., Flatt, T., and M. Tatar. 2006. Juvenile and steroid hormones in Drosophila melanogaster longevity. Chapter 16 (Pp. 415-448) in Handbook of the Biology of Aging, 6th Edition (Editors: Edward J. Masoro and Steven N. Austad), Academic Press (Elsevier), San Diego. Pdf

Flatt, T., Tu, M.-P., and M. Tatar. 2005. Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history. BioEssays 27:999-1010. (Cover Article) Pdf

Flatt, T. 2005. Juvenile hormone as an effector of metamorphosis and life history transitions. Integrative & Comparative Biology 45:997. (Published Abstract)

Flatt, T. 2005. The evolutionary genetics of canalization. Quarterly Review of Biology 80:287-316. Pdf

Altwegg, R., Dummermuth, S., Anholt, B.R., and T. Flatt. 2005. Winter weather affects asp viper (Vipera aspis aspis) population dynamics through susceptible juveniles. Oikos 110:55-66. Pdf

Flatt, T., and T.J. Kawecki. 2004. Pleiotropic effects of Methoprene-tolerant (Met), a gene involved in juvenile hormone metabolism, on life history traits in Drosophila melanogaster. Genetica 122:141-160. Pdf

Flatt, T., and I. Scheuring. 2004. Stabilizing factors interact in promoting host-parasite coexistence. Journal of Theoretical Biology 228:241-249. Pdf

Flatt, T. 2004. Assessing natural variation in genes affecting Drosophila lifespan. Mechanisms of Ageing and Development 125:155-159. Pdf

Rauch, G., Simon, J.-C., Chaubet, B., Haack, L., Flatt, T., and W.W. Weisser. 2002. The influence of ant attendance on aphid feeding behaviour investigated with the electrical penetration graph technique. Entomologia Experimentalis et Applicata 102:13-20. Pdf

Flatt, T., Shine, R., Borges-Landaez, P.A., and S.J. Downes. 2001. Phenotypic variation in an oviparous montane lizard: effects of thermal and hydric incubation environments. Biological Journal of the Linnean Society 74:339-350. Pdf

Flatt, T., Maire, N., and M. Doebeli. 2001. A bit of sex stabilizes host-parasite dynamics. Journal of Theoretical Biology 212:345-354. Pdf

Flatt, T., and W.W. Weisser. 2000. The effects of mutualistic ants on aphid life-history traits. Ecology 81:3522-3529. Pdf

Flatt, T., Dummermuth, S., and B.R. Anholt. 1997. Mark-recapture estimates of survival in populations of the asp viper, Vipera aspis aspis. Journal of Herpetology 31:558-564. Pdf